Common Drugs for LMS

 

Chemotherapy

(Cytotoxic – kills all fast growing heathy and cancerous cells in your body)

Doxorubicin/Adriamycin
Doxorubicin Liposomal/Doxil
Ifosfamide/Ifex
Docetaxol/Taxotere
DTIC/Decarbazine
Gembcitabene/Gemzar
Trabectedin/Yondelis (Specifically labelled for Leiomyosarcoma)
Epirubicin/Ellence
Temodar/Temozolomide

 

Targeted

(Disrupts pathways to cancer cell growth)
Bevacizumab/Avastin – angiogenesis Inhibitor Targets VEGF-A
Votrient/Pazopanib – Votrient targets tyrosine kinases
Nexavar/Sorafenib – tyrosine kinase inhibitor, angiogenesis inhibitor, VEGF inhibitor
Sutent/Sunitinib/SU11248 – tyrosine kinase inhibitor, VEGF & angiogenesis inhibitor

 

Hormonal Blockade

(Effects tumor growth by blocking hormones and hormone receptors)

Aromatase Inhibitors – Reversible
Letrozole/Femara
Arimidex/Anastrozole
Aromatase Inhibitors – Irreversible
Exemestane/Aromasin
Estrogen Receptor Modulators
Faslodex/Fulvestrant
Raloxifene/Evista
Tamoxifen – Not for Uterine LMS
Progesterone Analog
Megace/Megastrol

 

Supportive/Chemoprotective

(Agents added to protect healthy cells during cytotoxic chemo)

Mesna/Mesnex – Bladder Chemoprotectant (ifosfomide and cyclophosphamide)
Dexrazoxane – Cardio and Vascular Chemoprotectant (Doxorubicin)
Warfarin/Coumadin/Lovenox – Anticoagulent
Dexamethasone/Decadron – Adrenal Corticosteriod Supplement
Filgrastim/Neupogen – White Cell Production Booster
Pegfilgrastim/Neulasta – White Cell Production Booster
Sargramostim/Leukine – White Cell Production Booster
Zoledronic Acid/Zometa/Reclast – Bone and Serum Calcium Related
Lupron/leuprolide – Ovarian Estrogen Production Inhibitor
Zoladex/goserelin – Ovarian Estrogen Production Inhibitor